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Does Apomorphine Cross The Blood-Brain Barrier? Exploring Its Brain-Penetrating Potential

Nanoparticle-Mediated Brain Drug Delivery: Overcoming Blood–Brain Barrier  To Treat Neurodegenerative Diseases - Sciencedirect

Does Apomorphine Cross The Blood-Brain Barrier? Exploring Its Brain-Penetrating Potential

Crossing The Blood Brain Barrier: The Impact Of The Reynolds Professorship

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How Does Apomorphine Affect The Brain?

Apomorphine has a notable impact on the brain, primarily affecting its oxidative state and the activity of reactive astrocytes. Additionally, it leads to a reduction in the dendritic length of CA1 pyramidal neurons. Furthermore, this compound interferes with synaptic plasticity, specifically long-term potentiation (LTP) at CA3-CA1 synapses, which plays a crucial role in learning and memory processes. These effects collectively contribute to a deficit in learning and memory when apomorphine is introduced into the system, as reported on August 7, 2018.

What Are The Disadvantages Of Apomorphine?

Apomorphine is an effective medication used for various medical conditions, but it does come with some notable disadvantages. One significant drawback is its tendency to induce severe short-term nausea and vomiting in patients undergoing treatment. To mitigate these side effects, healthcare providers often prescribe an anti-sickness drug known as domperidone, commercially available as Motilium. It is essential to commence the domperidone treatment at least two days before initiating apomorphine therapy, allowing the anti-sickness medication to build up in your system for optimal effectiveness. As you progress with apomorphine treatment, your healthcare provider may gradually reduce the dosage of domperidone as your body becomes accustomed to the primary medication. This proactive approach to managing the side effects of apomorphine helps ensure a more comfortable and effective treatment experience for patients.

What Is The Difference Between Morphine And Apomorphine?

Many people wonder about the distinction between morphine and apomorphine. It’s important to clarify that despite its name, apomorphine doesn’t contain morphine or share its structural framework. Furthermore, apomorphine does not interact with opioid receptors in the same way that morphine does. The prefix “apo-” in apomorphine’s name actually refers to its origin as a derivative of morphine, indicating that it has a historical connection to morphine but differs significantly in its chemical structure and pharmacological actions.

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Nanoparticle-Mediated Brain Drug Delivery: Overcoming Blood–Brain Barrier  To Treat Neurodegenerative Diseases - Sciencedirect
Nanoparticle-Mediated Brain Drug Delivery: Overcoming Blood–Brain Barrier To Treat Neurodegenerative Diseases – Sciencedirect

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Crossing the Blood Brain Barrier: The Impact of the Reynolds Professorship
Crossing the Blood Brain Barrier: The Impact of the Reynolds Professorship

The hydrophilic character of apomorphine allows it to be solubilized and therefore, formulated as an aqueous solution. Moreover, it is readily mixed in tissue fluids and can be absorbed into the systemic circulation and subsequently cross the lipophilic blood-brain barrier [14].It causes an increase of the oxidative state and in the number of reactive astrocytes and a decrease in the dendritic length of CA1 pyramidal neurons. Furthermore, apomorphine impairs plasticity (LTP) at CA3–CA1 synapses and produces a deficit in learning and memory.Apomorphine can cause severe short-term nausea and sickness, so you may also be given an anti-sickness drug called domperidone (Motilium). You will need to start taking this at least two days before you begin your apomorphine treatment. Anti-sickness medication may be gradually reduced after a short while.

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